Archive for December, 2009

HIV drug resistance alert

By Claire Keeton | 30 December 2009
HIV drug resistance at about 5% in Sub-Saharan Africa

HIV drug resistance at about 5% in Sub-Saharan Africa

South Africa has initiated more than 700 000 people with HIV on antiretroviral drugs and – along with scaling up the rollout of treatment – a major challenge for 2010 and beyond will be containing drug resistance.

A presentation at the HIV Clinicians Society of Southern Africa this year outlined the increasing number of patients failing treatment, and the steps required to avert the widespread development of drug resistance.

The human cost of drug failure is vividly illustrated in an Associated Press feature from South Africa published today.

The Associated Press did a six-month investigation into soaring drug resistance to a range of diseases worldwide.

Among the key points this excellent story highlights are:
* HIV drug resistance ranges from 5% to 30% across the world, up from about 1% to 5% 10 years ago;
* HIV drug resistance is increasingly common in South Africa;
* Monitoring for HIV drug resistance is scarce in Sub-Saharan Africa, where the highest number of people have the virus;
* HIV drug resistance “mirrors the rise worldwide of new and more deadly forms of killer infections, such as tuberculosis and malaria. These diseases have mutated in response to the misuse of the (drugs),” the story says;
* “In some high-risk populations worldwide, HIV drug resistance rates soar as high as 80 percent”, according to studies published in the journal AIDS;
* Drug resistant strains could cost $44 billion to treat by 2010;
* Every year more drug resistant strains are detected: in 2008 there were 93, up from 80 different documented strains in 2007, according to Stanford University’s HIV Drug Resistance Database; and
* Adherence among children is difficult “because they depend on someone else to make sure the meds are swallowed”.

Should SA brand condoms with soccer balls for 2010?

By Claire Keeton | 26 December 2009
"Sex work has links to World Cup" says researcher

Cape Town’s mayor Dan Plato has dropped the ball: he has slammed a proposal, to brand condoms with soccer balls, as “nuts” for promoting prostitution.

In fact the innovative idea from the sex workers union (SWEAT) and the SA National AIDS Council (SANAC) is aiming to promote HIV prevention and awareness.

“I think they (Sweat and SANAC) are nuts thinking they can somehow promote prostitution through the World Cup,” Plato reportedly said.

He said there was “no way” he would condone the decriminalisation of prostitution and he was worried about “young girls on the streets”.

Young girls are particularly vulnerable to abuse while sex work remains illegal and underground.

SANAC’s health researcher Marlise Richter said: “Sex work has links to the World Cup, HIV/Aids, human rights, the law and public health.

“With the influx of an estimated 450 000 visitors to the country and with our high rates of HIV, it is critical that our laws create an environment (to achieve) the best possible public health outcomes.”

The decriminalisation of adult sex work in South Africa is under review and a paper by the SA Law Reform Commission, released this year, tabled four options from total criminalisation to non-criminalisation with regulation.

Adult sex work needs to be legalised to protect sex workers against violence and exploitation, reduce their risk of getting or spreading HIV and upholding labour and human rights.

Vivienne Lalu, SWEAT‘s advocacy officer told me: “We have been campaigning for decriminalisation for more than 14 years.

“Allegations that we are only pressing for 2010 spin-offs is a complete denial of not only sex worker rights, but human rights.

“The Amended Sexual Offences Bill to be delivered to the Department of Justice is due only in 2011,” she said.

Errol Naidoo, director of the Family Policy Institute, reportedly said he was concerned about reports that young girls were being trafficked into South Africa from rural areas and neighbouring countries to service visitors to the World Cup.

South Africa needs to create an environment to protect all sex workers ahead of the World Cup from violence and disease. 2010 condoms could contribute to this, and could even become souvenirs.

Body fat loss study more proof of why d4T must go

By Claire Keeton | 19 December 2009

Replace stavudine (d4T) in first line regimens

Substitute stavudine (d4T) in first line regimens

HIV activists, scientists and civil society should agitate for the speedy phasing out of d4T (stavudine), despite the steep price tag of its substitution, a new study suggests.
Stavudine is one of three drugs taken in South Africa’s for people starting ARV treatment (in other words, the first line regimen).
In a clinical review of lipoatrophy and other body fat changes on d4T-based regimens, Carole Leach-Lemens found “studies support the direct link between stavudine (d4T) and to a lesser extent zidovudine (AZT) and lipoatrophy”.
Other key points include:
• Lipoatrophy is a clinical diagnosis for (under the skin) fat loss when all other explanations have been ruled out making early diagnosis very difficult
• Early detection strategies are needed since changes in body shape are difficult to reverse
• Lipoatrophy is not life-threatening but the changes in appearance are psychologically damaging and stigmatising undermining adherence
• Most first-line regimens in resource-poor settings include either stavudine or zidovudine despite recent WHO recommendations to phase out stavudine. WHO recommends a reduced dose of stavudine when phasing out is not possible
• The substitution of stavudine with either tenofovir or abacavir has shown improvements in the form of weight gain and lipoatrophy scores
“All the available data suggest that patients receiving stavudine-based ART are at high risk of developing lipoatrophy and other body fat changes, and that risk rises as time on treatment lengthens,” Leach-Lemens reported in the NAM publication, HATIP (HIV & AIDS Treatment in Practice).
“While peripheral neuropathy (pain and tingling in the hands, arm, feet and legs) is difficult to ignore when it is causing crippling pain, many people with HIV do seem to live with lipoatrophy without complaint to their health care providers, accepting it as the price that must be paid for lifegiving treatment,” she found.
“Yet there is good evidence that eventually the stigmatising effect of lipoatrophy undermines treatment adherence, and has a profound effect on quality of life.”
Leach-Lemens concluded: “In the case of first-line treatment, change will not be cheap, but the long-term cost of doing nothing will be to consign a very large number of people to years of treatment with drugs that are not just sub-optimal, but downright harmful.”

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Let’s not whitewash Dr Manto Tshabalala-Msimang’s legacy

By Claire Keeton | 17 December 2009
The end of an era

The end of an era

Former health minister, Dr Manto Tshabalala-Msimang passed away yesterday, on South Africa’s Day of Reconciliation December 16, at the age of 69.

Condolences are due to her family and loved ones as they grieve.

But I don’t think respect and reconciliation require being silent about her disastrous mistakes – estimated to amount to at least 330 000 lives lost to AIDS between 2000 and 2005.

Yes, she was a veteran activist who committed her youth to overcoming injustice and apartheid and she should be honoured for that. But her leadership as as health minister for almost decade (1999 to 2009) was catastrophic.

The book “The Virus, Vitamins & Vegetables, The SA HIV/AIDS mystery” – in which I have a vested interest having written a chapter -documents how she and former President Thabo Mbeki allowed the HIV/AIDS epidemic to spiral out of control and obstructed the rollout of antiretroviral treatment.

“The book chronics the tragedy that unfolds when leaders choose to play with people’s lives”, former deputy health minister, Nozizwe Madlala-Routledge, said at its launch.

“Dr No” didn’t only do untold damage in HIV/AIDS, she also exacerbated the decline of the public health system in many ways, including driving dedicated doctors out of the public service and undermining scientific programmes.

As Professor Francois Venter, president of the HIV Clinicians Society of Southern Africa, said: “The family should be allowed to grieve in privacy.

“Equally, political leaders should keep eulogizing to a bare minimum, to respect the large number of people who died unnecessarily of HIV or who suffered at the hands of a decimated health system.”

Today Anglican Archbishop Thabo Makgoba, extended condolences to those who grieve for her passing and urged South Africans to move forward determined to fight the scourge of HIV/AIDS.

“Let us use the death of Dr Tshabalala-Msimang as a milestone on our journey, a signpost towards a future with an Aids-free South Africa,” he urged. Let’s do that.

Time to celebrate: SA’s best World AIDS Day

By Claire Keeton | 1 December 2009
    This World AIDS Day will go down in SA as an historic event. Thank you President Zuma and Dr Motsoaledi!

    It is the first time on World AIDS Day that South Africa’s leaders have announced such good news: from April all babies under one years old will be able to get antiretroviral treatment and adults will be able to access to antiretrovirals with a CD4 count of 350 (up from the low bar of 200) – in line with international guidelines.

    The government is also scaling up HIV testing, with Zuma and Motsoaledi indicating they will take HIV tests themselves.

    I’m going away for two weeks and this is the perfect way to start my holiday. Will be back on December 16.